• N. Z. Med. J. · Nov 2004

    Comparative Study

    Specific oral contraceptive use and venous thromboembolism resulting in hospital admission.

    • Patricia Heuser, Katrina Tonga, Raewyn Hopkins, Marissa Henderson, Mark Weatherall, Scott Metcalfe, and Richard Beasley.
    • Medical Research Institute of New Zealand, Wellington, New Zealand.
    • N. Z. Med. J. 2004 Nov 26; 117 (1206): U1176.

    ObjectiveTo determine whether there is an increased risk of venous thromboembolism (VTE) with anti-androgen oral contraceptives containing cyproterone acetate and ethinyloestradiol.MethodsComparison of the frequency of specific oral contraceptive use in patients aged 15 to 55 years discharged from hospital with radiologically confirmed deep vein thrombosis (DVT) and/or pulmonary embolism (PE) with the expected frequency of use derived from national prescription data.Main Outcome MeasureRatio of observed frequency of specific oral contraceptive use in patients with VTE versus expected frequency of use.ResultsThe rank order for observed versus expected use was anti-androgen > third-generation, > second-generation, > progestogen-only oral contraceptive agents with ratios of 1.93, 1.36, 0.70, and 0.39, respectively.ConclusionThe risk of VTE resulting in hospital admission associated with anti-androgen oral contraceptive use is at least as high as with third generation use.

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