• Biological psychiatry · Jun 2013

    Review

    Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond.

    • John H Krystal, Gerard Sanacora, and Ronald S Duman.
    • Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA. john.krystal@yale.edu
    • Biol. Psychiatry. 2013 Jun 15; 73 (12): 1133-41.

    AbstractTraditional antidepressants require many weeks to reveal their therapeutic effects. However, the widely replicated observation that a single subanesthetic dose of the N-methyl-D-aspartate glutamate receptor antagonist ketamine produced meaningful clinical improvement within hours, suggested that rapid-acting antidepressants might be possible. The ketamine studies stimulated a new generation of basic antidepressant research that identified new neural signaling mechanisms in antidepressant response and provided a conceptual framework linking a group of novel antidepressant mechanisms. This article presents the path that led to the testing of ketamine, considers its promise as an antidepressant, and reviews novel treatment mechanisms that are emerging from this line of research.Published by Elsevier Inc.

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