• Clin. Pharmacol. Ther. · Feb 2012

    Review

    Ketamine as a novel antidepressant: from synapse to behavior.

    • J W Murrough.
    • Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA. james.murrough@mssm.edu
    • Clin. Pharmacol. Ther. 2012 Feb 1; 91 (2): 303-9.

    AbstractRecent reports of a rapid antidepressant effect of the glutamate N-methyl-D-aspartate (NMDA) receptor antagonist ketamine, even in treatment-resistant populations, have spurred translational therapeutic and neuroscience research aimed at elucidating ketamine's mechanism of action. This article provides a concise overview of research findings that pertain to the effects of low-dose ketamine at the cellular, neurocircuitry, and behavioral levels and describes an integrated model of the action of ketamine in the treatment of depression.

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