-
Neuroscience research · Feb 2012
New method to discriminate sedative and analgesic effects of drugs in the automated formalin test in rats.
- Stéphanie Grégoire, Monique Etienne, Marie Gaulmin, François Caussade, Didier Neuzeret, and Denis Ardid.
- Clermont Université, Université d'Auvergne, Pharmacologie Fondamentale et Clinique de la Douleur, INSERM U766, BP 10448, F-63000 Clermont-Ferrand, France. stephanie.gregoire.sg@gmail.com
- Neurosci. Res. 2012 Feb 1; 72 (2): 194-8.
AbstractWe developed an automated technique based on the detection of pain-related behaviours (like licking or biting) and small activities (mostly grooming) in the formalin pain test. By comparing automated and manual scoring, we determined that the interphase score was mostly independent of pain-related behaviours and it was used as an index of sedative events. The non-pain-related behaviours, still present during the second phase, were eliminated in order to visualize only pain-related behaviours. This new method, validated using classical analgesic (morphine) and sedative drugs (diazepam) could be used to discriminate sedative from analgesic effects of pharmacological treatments in the formalin test.Copyright © 2011 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*
,_underline_
or**bold**
. - Superscript can be denoted by
<sup>text</sup>
and subscript<sub>text</sub>
. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3.
, hyphens-
or asterisks*
. - Links can be included with:
[my link to pubmed](http://pubmed.com)
- Images can be included with:
![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
- For footnotes use
[^1](This is a footnote.)
inline. - Or use an inline reference
[^1]
to refer to a longer footnote elseweher in the document[^1]: This is a long footnote.
.