• Juan C Celedón, Donald K Milton, Clare D Ramsey, Augusto A Litonjua, Louise Ryan, Thomas A E Platts-Mills, and Diane R Gold.
• Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. juan.celedon@channing.harvard.edu
• J. Allergy Clin. Immunol. 2007 Jul 1; 120 (1): 144-9.

BackgroundThere has been no longitudinal study of the relation between concurrent exposure to dust mite allergen and endotoxin in early life and asthma and atopy at school age.ObjectivesTo examine the relation between exposure to dust mite allergen and endotoxin at age 2 to 3 months and asthma, wheeze, and atopy in high-risk children.MethodsBirth cohort study of 440 children with parental history of atopy in the Boston metropolitan area.ResultsIn multivariate analyses, early exposure to high levels of dust mite allergen (> or =10 microg/g) was associated with increased risks of asthma at age 7 years (odds ratio [OR], 3.0; 95% CI, 1.1-7.9) and late-onset wheeze (OR, 5.0; 95% CI, 1.5-16.4). Exposure to endotoxin levels above the lowest quartile at age 2 to 3 months was associated with reduced odds of atopy at school age (OR, 0.5; 95% CI, 0.2-0.9). In contrast with its inverse association with atopy, endotoxin exposure in early life was associated with an increased risk of any wheeze between ages 1 and 7 years that did not change significantly with time (hazard ratio for each quartile increment in endotoxin levels, 1.23; 95% CI, 1.07-1.43).ConclusionAmong children at risk of atopy, early exposure to high levels of dust mite allergen is associated with increased risks of asthma and late-onset wheeze. In these children, endotoxin exposure is associated with a reduced risk of atopy but an increased risk of wheeze.Clinical ImplicationsEarly endotoxin exposure may be a protective factor against atopy but a risk factor for wheeze in high-risk children.

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