• Interact Cardiovasc Thorac Surg · Nov 2009

    Postoperative administration of landiolol hydrochloride for patients with supraventricular arrhythmia: the efficacy of sustained intravenous infusion at a low dose.

    • Seiichiro Wariishi, Koichi Yamashita, Hideaki Nishimori, Takashi Fukutomi, Masaki Yamamoto, Geethalakshmi Radhakrishnan, and Shiro Sasaguri.
    • Department of Surgery II, Kochi University, Kohasu, Nankoku, Kochi, Japan. wari@kochi-u.ac.jp
    • Interact Cardiovasc Thorac Surg. 2009 Nov 1; 9 (5): 811-3.

    AbstractThe purpose of this study was to investigate the efficacy of landiolol hydrochloride, a short-acting beta(1) blocker, by initiating its administration at a low dose (5 microg kg(-1) min(-1)) in patients with postoperative supraventricular arrhythmia. The efficacy of landiolol was evaluated in 38 patients who, after developing postoperative atrial flutter or fibrillation, with sinus tachycardia and two patients who had a history of paroxysmal atrial fibrillation with frequent atrial extrasystole. The heart rate and blood pressure before and 2 h after the administration of landiolol were compared. A return to the sinus rhythm from supraventricular arrhythmia was noted in 89%. The heart rate was reduced from 137+/-26 bpm (before landiolol administration) to 93+/-18 bpm (2 h after the start of the medication, P<0.01). As an agent to correct an arrhythmic condition, landiolol successfully raised the systolic blood pressure from 108+/-24 mmHg (before medication) to 120+/-19 mmHg (2 h after the medication was started, P<0.05). Continuous intravenous infusion of landiolol at a low dose was found to be effective for postoperative supraventricular arrhythmia.

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