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Clin. Pharmacol. Ther. · Jan 2009
CommentSafety issues of maternal drug therapy during breastfeeding.
- C M Berlin, I M Paul, and E S Vesell.
- Department of Pediatrics, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA. cmb6@psu.edu
- Clin. Pharmacol. Ther. 2009 Jan 1; 85 (1): 20-2.
AbstractTwo goals when counseling breastfeeding mothers taking medication are protecting the infant from adverse events and permitting necessary maternal therapy. Madadi et al. report a case-control study of neonatal and maternal opioid toxicity after codeine administration. Therapeutic considerations in counseling breastfeeding mothers include susceptibility to drug toxicity of the very young and/or premature infant, significant interindividual variations in drug response, the dose-response relationship with respect to drug toxicity, and the role of pharmacogenetics in both the mother and the infant. These host factors may combine in a particular patient to act synergistically to produce an adverse reaction.
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