• N C Lindfors, P Hyvönen, M Nyyssönen, M Kirjavainen, J Kankare, E Gullichsen, and J Salo.
• Department of Orthopaedic and Hand Surgery, Helsinki University Central Hospital, Helsinki University, Helsinki, Finland. nina.c.lindfors@hus.fi
• Bone. 2010 Aug 1; 47 (2): 212-8.

AbstractBioactive glass (BAG)-S53P4 is an osteoconductive bone substitute with proven antibacterial and bone bonding properties. In a multicentre study 11 patients with verified chronic osteomyelitis in the lower extremity and the spine were treated with BAG-S53P4 as a bone substitute. The cavitary bone defect and the surrounding of a spinal implant were filled with BAG-S53P4. The most common pathogen causing the infection was Staphylococcus aureus. The mean follow-up was 24 months (range 10-38). BAG-S53P4 was well tolerated. Nine patients healed without complications. One patient who achieved good bone formation sustained a superficial wound infection due to vascular problems in the muscle flap, and one patient had an infection due to a deep haematoma. This study shows that BAG-S53P4 is a good and well-tolerated bone substitute, and can be used in treatment of osteomyelitis with good primary results.

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