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- Adrien Bouglé, Pierre Rocheteau, Tarek Sharshar, and Fabrice Chrétien.
- Human Histopathology and Animal Models Unit, Infection and Epidemiology Department, Institut Pasteur, 75724 cedex15, Paris, France. adrien.bougle@aphp.fr.
- Crit Care. 2016 May 19; 20 (1): 131.
AbstractSevere critical illness is often complicated by intensive care unit-acquired weakness (ICU-AW), which is associated with increased ICU and post-ICU mortality, delayed weaning from mechanical ventilation and long-term functional disability. Several mechanisms have been implicated in the pathophysiology of ICU-AW, but muscle regeneration has not been investigated to any extent in this context, even though its involvement is suggested by the protracted functional consequences of ICU-AW. Recent data suggest that muscle regeneration could be impaired after sepsis, and that mesenchymal stem cell treatment could improve the post-injury muscle recovery.
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