• J Neuropsychiatry Clin Neurosci · Jan 2009

    Review

    Psychopharmacological treatment for cognitive impairment in survivors of traumatic brain injury: a critical review.

    • Brian W Writer and Jason E Schillerstrom.
    • University of Texas Health Science Center San Antonio, Psychiatry, 59 MHS/SGOWV1, 2200 Bergquist Dr., Suite 1, Lackland AFB TX 78236-5300, USA. brian.writer@lackland.af.mil
    • J Neuropsychiatry Clin Neurosci. 2009 Jan 1; 21 (4): 362-70.

    AbstractTraumatic brain injury (TBI) is a growing national health issue that commonly results in clinically significant cognitive impairments. This article reviews and evaluates the many proposed psychopharmacological treatments for TBI-related cognitive impairment. A literature review was utilized to focus on stimulant and nonstimulant dopamine enhancing agents, acetylcholinesterase inhibitors, antidepressant agents, mood stabilizers, antipsychotics, and benzodiazepines. The most consistent evidence supports the use of dopamine enhancing medications. However, other medications such as acetylcholinesterase inhibitors and antidepressant agents may help select subgroups. A need remains for well designed, sufficiently powered studies that incorporate functionally relevant neuropsychological outcome measures.

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