• Best Pract Res Clin Haematol · Sep 2012

    Review

    The promise of novel direct oral anticoagulants.

    • Ron Hoffman and Benjamin Brenner.
    • Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel. r_hoffman@rambam.health.gov.il
    • Best Pract Res Clin Haematol. 2012 Sep 1; 25 (3): 351-60.

    AbstractThe standard effective treatment of venous and arterial thromboembolism includes unfractionated and low-molecular weight heparin as well as warfarin, which have major disadvantages. In recent years, new anticoagulants have been developed in an attempt to overcome the known limitations of established treatment and develop improved therapies. This chapter reviews pharmacological properties of the new anticoagulants, the most recent trials assessing their safety and efficacy as well as potential advantages and disadvantages of using these novel drugs in real life.Copyright © 2012 Elsevier Ltd. All rights reserved.

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