• Epilepsy & behavior : E&B · Dec 2010

    Case Reports

    Does lacosamide aggravate Lennox-Gastaut syndrome? Report on three consecutive cases.

    • Antonella Cuzzola, Edoardo Ferlazzo, Domenico Italiano, Rocco Salvatore Calabrò, Placido Bramanti, and Pierre Genton.
    • Hôpital Henri Gastaut, Centre Saint-Paul, Marseille, France.
    • Epilepsy Behav. 2010 Dec 1; 19 (4): 650-1.

    AbstractLennox-Gastaut syndrome is an intractable epileptic encephalopathy, with most patients experiencing daily seizures despite therapy with multiple antiepileptic drugs. New treatments need to be tested to define their efficacy in this syndrome. Lacosamide is a new antiepileptic drug recently approved for the treatment of partial-onset seizures. We describe three patients with Lennox-Gastaut syndrome resistant to conventional antiepileptic drugs whose seizures were aggravated by lacosamide.Copyright © 2010 Elsevier Inc. All rights reserved.

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