• Pharmacogenomics · Nov 2003

    Review

    Pharmacogenomics in the treatment of epilepsy.

    • Colleen E Clancy and Robert S Kass.
    • Department of Pharmacology, Columbia University, College of Physicians and Surgeons, 630 W. 168th Street, New York, NY 10032, USA. rsk20@columbia.edu
    • Pharmacogenomics. 2003 Nov 1; 4 (6): 747-51.

    AbstractGenetic variability has recently been implicated in the development of familial epilepsy syndromes and in heterogeneous responses of epilepsy patients to drug treatment. Mutations in distinct proteins have been shown to underlie the development of epilepsy, increase propensity for drug resistance, and alter drug metabolism. Improved understanding of how individual genetic variability may alter the efficacy of pharmacological therapeutic interventions is an important and timely goal. The investigation of relationships between genotype and patient responses to drug treatment is termed pharmacogenomics.

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