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- Philippe Girard, Yannick Pansart, Marie-Claude Coppé, Betty Niedergang, and Jean-Marie Gillardin.
- Biocodex, Service de Pharmacologie, Compiègne, France.
- Pharmacology. 2009 Jan 1; 83 (4): 243-6.
Background/AimsPost-operative nausea and vomiting are common adverse events that require administration of anti-emetic compounds, such as the serotonin 5-HT(3) receptor antagonists, but these drugs can also reduce the analgesic efficacy of some analgesics (paracetamol, tramadol).MethodsThe present study was designed to explore the effect of 3 serotonin 5-HT(3) receptor antagonists on the antinociceptive efficacy of another frequently used post-operative analgesic, nefopam, in the mouse writhing and formalin tests.ResultsPre-treatment with tropisetron, ondansetron or MDL72222 did not significantly modify nefopam antinociception in both tests. However, paracetamol antinociception was blocked by ondansetron in the formalin test.ConclusionThese results provide a rationale for the clinical use of nefopam with anti-emetics during surgery.Copyright 2009 S. Karger AG, Basel.
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