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  • Fertility and sterility · Mar 2010

    Comparative Study

    Effect of pentoxifylline on vascular endothelial growth factor C and flk-1 expression on endometrial implants in the rat endometriosis model.

    • Nikos F Vlahos, Odysseas Gregoriou, Aikaterini Deliveliotou, Despoina Perrea, Athanasios Vlachos, Yulian Zhao, Joseph Lai, and George Creatsas.
    • Second Department of Obstetrics and Gynecology, University of Athens Medical School, Aretaieion Hospital, 76 Vas. Sofias Av., Athens 11521, Greece. nvlahos@jhmi.edu
    • Fertil. Steril. 2010 Mar 1; 93 (4): 1316-23.

    ObjectiveTo investigate the effects of pentoxifylline, on vascular endothelial growth factor (VEGF)-C and flk-1 expression in the rat endometriosis model.DesignProspective, randomized, placebo-controlled study.SettingAcademic institution.Animal(S)Twenty Wistar rats with surgically induced endometriosis.Intervention(S)Animals were evaluated after surgical induction of endometriosis and random allocation to a group that received pentoxifylline and a control group that received NaCl 0.9%, for 3 weeks. At the end of the treatment period the animals were killed and the implants evaluated macroscopically as well as by immunohistochemistry.Main Outcome Measure(S)Morphologic changes of the endometriotic implants; and evaluation of VEGF-C and flk-1 expression by a semiquantitative analysis (HSCORE) for the intensity of immunohistochemical reactivity.Result(S)A significant reduction was observed in the mean volume of the endometriotic implants per animal in the treatment group as compared with the control group. There was a significant reduction not only in the mean volume of implants per animal but also in the mean number of implants per animal after treatment. By immunohistochemical evaluation (HSCORE), there was a significant reduction in VEGF-C expression after treatment in all areas examined. A significant reduction of flk-1 expression was also noted in the glandular compartment after treatment but not in the epithelial surface or stroma.Conclusion(S)Pentoxifylline may cause suppression of endometriotic lesions by suppressing angiogenesis through VEGF-C and flk-1 expression.Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

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