• Renee Romeo, Martin Knapp, Sube Banerjee, Julie Morris, Robert Baldwin, Nicholas Tarrier, Neil Pendleton, Mike Horan, and Alistair Burns.
• King's College London, Institute of Psychiatry, United Kingdom. renee.romeo@kcl.ac.uk
• J Affect Disord. 2011 Feb 1; 128 (3): 211-9.

ObjectiveFor older people who have had hip fracture surgery, to evaluate the cost-effectiveness of a nurse-led intervention in treating depression compared to treatment as usual (TAU), and to evaluate the cost-effectiveness of a psychological treatment for the prevention of depression.DesignTwo linked cost-effectiveness studies for the treatment and prevention of depression after hip surgery, from the perspective of health, social care, voluntary sector agencies and unpaid carers.SettingOrthopaedic units in Manchester, England.ParticipantsOne hundred and twenty-one patients with Geriatric Depression Scale (GDS) scores greater than 6 were included in the treatment study and 172 patients with GDS scores less than or equal to 6 were enrolled in the prevention study.InterventionsNurse-led intervention for treating depression versus TAU; and cognitive behaviour therapy (CBT) for preventing depression following surgery for hip fracture.Main Outcome MeasuresOutcomes were changes in HADS-depression scores at 6 weeks. Costs covered treatment and all service impacts.ResultsAfter 6 weeks, there were no significant differences in cost. However, the nurse-led intervention group had a lower mean HADS-depression score compared to TAU. In the prevention study, there were no significant differences in cost and depression score between patients treated with CBT and TAU.ConclusionThe results for this parallel randomized controlled study show that after hip fracture surgery a nurse-led intervention may be a cost-effective option for the treatment of depression in older people with depression. However CBT does not appear to be a cost-effective option for the prevention of depression in this population.© 2010 Elsevier B.V. All rights reserved.

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