• Neth J Med · Sep 2011

    Case Reports

    A case of hyperammonaemic encephalopathy due to valproic acid.

    • M C Prins and J J van Meijel.
    • Department of Internal Medicine, Sint Lucas Andreas Hospital, Amsterdam, The Netherlands. meikeprins@hotmail.com
    • Neth J Med. 2011 Sep 1; 69 (9): 389-91.

    AbstractA patient with valproic acid induced hyperammonaemic encephalopathy is presented. During chronic treatment with valproic acid this patient developed a potentially life-threatening encephalopathy without signs of liver failure. After discontinuing the valproic acid the patient recovered completely. In the case of a patient presenting with hyperammonaemic encephalopathy, the possibility of the use of valproic acid should not be overlooked.

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