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Cardiovasc Diagn Ther · Oct 2015
ReviewVascular repair strategies in type 2 diabetes: novel insights.
- Kira Kuschnerus, Ulf Landmesser, and Nicolle Kränkel.
- Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik für Kardiologie, Berlin, Germany.
- Cardiovasc Diagn Ther. 2015 Oct 1; 5 (5): 374-86.
AbstractImpaired functions of vascular cells are responsible for the majority of complications in patients with type 2 diabetes (T2D). Recently a better understanding of mechanisms contributing to development of vascular dysfunction and the role of systemic inflammatory activation and functional alterations of several secretory organs, of which adipose tissue has more recently been investigated, has been achieved. Notably, the progression of vascular disease within the context of T2D appears to be driven by a multitude of incremental signaling shifts. Hence, successful therapies need to target several mechanisms in parallel, and over a long time period. This review will summarize the latest molecular strategies and translational developments of cardiovascular therapy in patients with T2D.
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