• M Sai Sunil Kishore, Sourabh Dutta, and Praveen Kumar.
• Division of Neonatology, Department of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
• Acta Paediatr. 2009 Sep 1; 98 (9): 1412-5.

AimTo determine whether early nasal intermittent positive pressure ventilation (NIPPV), in comparison to early continuous positive airway pressure (CPAP), can reduce the need for intubation and mechanical ventilation in preterm neonates with suspected respiratory distress syndrome (RDS).MethodsIn this stratified open-label randomized controlled trial, neonates (28-34 weeks gestation) with respiratory distress within 6 h of birth and Downe's score >or= 4 were eligible. Subjects were randomly allocated to 'early-NIPPV' or 'early-CPAP' after stratifying for gestation (28-30 weeks, 31-34 weeks) and surfactant use. Primary outcome was failure of the allocated mode within 48 h.ResultsSeventy-six neonates were enrolled (37 in 'early-NIPPV' and 39 in 'early-CPAP' groups). Failure rate was less with 'early-NIPPV' versus 'early-CPAP'[13.5% vs. 35.9%, respectively, RR 0.38 (95% CI 0.15-0.89), p = 0.024]. Similarly, need for intubation and mechanical ventilation by 7 days (18.9% vs. 41%, p = 0.036) was less with NIPPV. Failure rate with NIPPV was less in the subgroups of subjects born at 28-30 weeks (p = 0.023) and who did not receive surfactant (p = 0.018).ConclusionAmong preterm infants with suspected RDS, early use of NIPPV reduces the need for intubation and mechanical ventilation compared to CPAP.

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