• Can J Anaesth · Nov 1992

    Review

    The use of muscle relaxants in the intensive care unit.

    • M D Sharpe.
    • W.E. Spoerel Intensive Care Unit, University Hospital, Department of Anaesthesia, University of Western Ontario, London.
    • Can J Anaesth. 1992 Nov 1; 39 (9): 949-62.

    AbstractNeuromuscular blocking agents are frequently used in the Intensive Care Unit to facilitate tracheal intubation and the application of continuous paralysis. This review will focus on various conditions of the critically ill patient such as multi-organ dysfunction, acid-base and electrolyte imbalance, prolonged immobility, multiple drug interactions and specific disease/injury processes that may affect the pharmacokinetic and pharmacodynamic behaviour of muscle relaxants. As such, due to the complex nature of the critically ill patients, the effects of neuromuscular blocking agents are unpredictable. Therefore, guidelines regarding their administration and the methodology and requirement for continuous bedside monitoring of neuromuscular function will be presented.

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