• R Wiesemes and J Peters.
• Institut für Klinische Anästhesiologie, Heinrich-Heine-Universität Düsseldorf.
• Anasthesiol Intensivmed Notfallmed Schmerzther. 1993 Aug 1; 28 (5): 269-78.

AbstractSince mixed venous oxygen saturation (SvO2) depends on O2-supply and O2-consumption, its measurement is said to indicate tissue O2-balance and to be suitable for ensuring tissue oxygenation in critically ill patients. Blood for SvO2 determinations should be drawn exclusively from the pulmonary artery, because mixing of systemic venous blood is incomplete in the right atrium and ventricle. SvO2 can be determined in vitro and in vivo. Current in vivo techniques determine oxygen saturation from the relation between light emitted into the blood stream and that reflected from blood cells, the use of 3 instead of 2 wavelengths greatly improving the accuracy of the method. For reasonable interpretation of SvO2 it is necessary to consider the concentration of haemoglobin and its derivatives, shifts of the O2-dissociation curve, intracardiac left-to-right shunts, and systemic arteriovenous shunts. Disturbances of macrocirculation (e.g. vascular surgery) and microcirculation (e.g. sepsis) also impair the diagnostic value of SvO2 determinations. The critical value of SvO2 appears to depend on the prevailing disease. Patients with chronically impaired O2 transport appear to tolerate very low SvO2 values better than acutely ill patients, presumably due to adaptive changes in the former group. Central venous oxygen saturation may indicate directional changes of the SvO2, but does not estimate the real SvO2-value. The hypothesis that continuous SvO2 measurements improve prognosis or lower treatment costs has not yet been confirmed. Measurements of mixed venous oxygen saturation may improve monitoring and treatment of critically ill patients in selected cases; however, these measurements are not suitable to indicate reliably the status of tissue oxygenation under all conditions.

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