• Critical care clinics · Apr 2011

    Review

    Biomarkers: the future.

    • Steven P LaRosa and Steven M Opal.
    • Warren Alpert School of Medicine, Brown University, 171 Meeting Street, Providence, RI 02912, USA. slarosa@lifespan.org
    • Crit Care Clin. 2011 Apr 1; 27 (2): 407-19.

    AbstractThe future application of biomarkers in critical illness will be to select and guide therapy. Specific biomarkers could identify a pathophysiologic perturbation or noxious mediator to counteract or the need to replete a deficient protective protein. Functional genomics could identify patients at risk for illness or at risk for a poor outcome in critical illness. Genetic expression studies could help differentiate patients with sepsis from those with noninfectious inflammation and could also help to monitor illnesses over time. Expressional and functional proteomics could lead to the identification of new biomarkers and organ-specific therapies.Copyright © 2011 Elsevier Inc. All rights reserved.

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