• Nasim Maleki, Gabi Barmettler, Eric A Moulton, Steven Scrivani, Rosanna Veggeberg, Egilius L H Spierings, Rami Burstein, Lino Becerra, and David Borsook.
• aDepartment of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA bCenter for Pain and the Brain and PAIN Group, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA cDepartment of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA, USA dDepartment of Psychiatry, PAIN Group, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA, USA eDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA fAnesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
• Pain. 2015 Jul 1;156(7):1232-9.

AbstractGray matter loss in cortical regions is a normal ageing process for the healthy brain. There have been few studies on the process of ageing of the brain in chronic neurological disorders. In this study, we evaluated changes in the cortical thickness by age in 92 female subjects (46 patients with migraine and 46 healthy controls) using high-field magnetic resonance imaging. The results indicate that in contrast to healthy subjects, migraineurs show a lack of thinning in the insula by age. The functional significance of the lack of thinning is unknown, but it may contribute to the overall cortical hyperexcitability of the migraine brain because the region is tightly involved in a number of major brain networks involved in interoception, salience, nociception, and autonomic function, including the default mode network.

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