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Acta medica Scandinavica · Jan 1982
Case ReportsNeurogenic pulmonary oedema. A review of the pathophysiology with clinical and therapeutic implications.
- M Lagerkranser, K Pehrsson, and C Sylvén.
- Acta Med Scand. 1982 Jan 1; 212 (4): 267-71.
AbstractFive cases of neurogenic pulmonary oedema (NPE) are described. The causes were mechanical trauma to the skull, subarachnoid haemorrhage and epileptic seizure. In every case a frank pulmonary oedema was diagnosed that resolved within a few days. Treatment of the underlying disease resulted in a favourable outcome. The literature has been reviewed. The basic mechanism seems to be an increased intracranial pressure (ICP) precipitating an increased central sympathetic nerve activity mediated via peripheral alpha- or beta-adrenergic discharge. NPE results from a predominant alpha-receptor stimulation with massive increase in pre- and afterload. The major therapeutic efforts should be directed towards the underlying cause and, in addition, mechanical ventilation with passive hyperventilation is vital. High positive end-expiratory pressure should not be used without strict monitoring of ICP.
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