-
Antimicrob. Agents Chemother. · Jan 2014
Efflux inhibition with verapamil potentiates bedaquiline in Mycobacterium tuberculosis.
- Shashank Gupta, Keira A Cohen, Kathryn Winglee, Mamoudou Maiga, Bassirou Diarra, and William R Bishai.
- Center for Tuberculosis Research, Department of Medicine, JHU, Baltimore, Maryland, USA.
- Antimicrob. Agents Chemother. 2014 Jan 1; 58 (1): 574-6.
AbstractDrug efflux is an important resistance mechanism in Mycobacterium tuberculosis. We found that verapamil, an efflux inhibitor, profoundly decreases the MIC of bedaquiline and clofazimine to M. tuberculosis by 8- to 16-fold. This exquisite susceptibility was noted among drug-susceptible and drug-resistant clinical isolates. Thus, efflux inhibition is an important sensitizer of bedaquiline and clofazimine, and efflux may emerge as a resistance mechanism to these drugs.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..