• Wei-jun Fu, Miao-ning Gu, Zhong-qing Chen, Jin-fang Xiao, Yi-ran Huang, Wei Zhou, and Ye-ming Chen.
• SICU Seawater Research Team, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
• Di Yi Jun Yi Da Xue Xue Bao. 2004 Jun 1; 24 (6): 665-9.

ObjectiveTo study the mechanism of respiratory distress syndrome (RDS) induced by immersion in seawater to provide experimental evidence for its treatment.MethodsTwelve normal hybrid dogs were randomly assigned into control group (n=4) and SDS model group (n=8). The changes in blood dynamics, blood gas analysis and histological changes in the lung tissues were compared between the 2 groups. The concentration of lactic dehydrogenase (LDH-L) and alkaline phosphatase (ALP) in the bronchoalveolar fluid and blood of the dogs in the model group were tested.ResultsThe blood dynamics, blood gas analysis and histology of the dogs in the model group were significantly different from those in the control group, and LDH-L and ALP levels increased significantly in the bronchoalveolar fluid of the model group.ConclusionSeawater aspiration into the lungs may lead to RDS, and the canine models used in this study may help explore the mechanism and management of RDS induced by immersion in seawater.

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