• John F Bishop.
• Bishop & Associates, Inc, 1963 Hunters Court, Wellington, FL 33414, USA. bishopjf@aol.com
• Crit Care Nurs Clin North Am. 2004 Mar 1; 16 (1): 145-77.

AbstractIdeally, in a burn-traumatized patient, nonviable skin and tissues should be excised early in the course of treatment and replaced with a graftable material that mimics the properties of normal skin in function,texture, sensation, and appearance. The difficulty in identifying indeterminate-depth dermal injuries requires further studies to establish the line between extending injury and delaying the progressive excision of nonviable tissue. Recent studies have shown that molecularly the process of wound healing is an interaction among multiple macromolecules and therefore requires in-depth studies of growth factor symptoms, the extra-cellular matrix, and the immunologic response to wounds [8788].The survival of patients with major thermal injuries (Fig. 35) has dramatically increased in recent years. Therefore, greater emphasis must be placed on improving the overall treatment process and the quality of the end result for these patients. Surgically directed and laboratory-based investigations into the cellular components of wound repair and the development of alternative methods of final wound closure are continuing to evolve, and bum specialists are,optimistic that new alternatives will become available for their patients.

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