• Zhejiang Da Xue Xue Bao Yi Xue Ban · Jul 2015

    Comparative Study

    [Comparison clinical efficacy of 3% hypertonic saline solution with 20% mannitol in treatment of intracranial hypertension in patients with aneurysmal subarachnoid hemorrhage].

    • Xue-cai Huang and Ling-ling Yang.
    • Department of Neurosurgery, Lishui Central Hospital, Lishui 323000, China.
    • Zhejiang Da Xue Xue Bao Yi Xue Ban. 2015 Jul 1; 44 (4): 389-95.

    ObjectiveTo compare the efficacy of 3% hypertonic saline solution with 20% mannitol in treatment of intracranial hypertension in patients with aneurysmal subarachnoid hemorrhage.MethodsAn alternating treatment protocol was used to compare the efficacy of 160 mL 3% hypertonic saline solution (HSS) with 150 mL 20% mannitol for episodes of increased intracranial pressure (ICP) in patients with aneurysmal subarachnoid hemorrhage. The dependent variables were the extent and duration of reduction of increased ICP after each event.ResultsBoth 3% HSS and 20% mannitol rapidly decreased the ICP in patients with aneurysmal subarachnoid hemorrhage (P <0.01). No difference between two medications in the extent of duration of ICP and reduction of action (P >0.05).Conclusion3% HSS should be considered as the first-line osmotic drug in treatment of intracranial hypertension in patients with aneurysmal subarachnoid hemorrhage.

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