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- T Hakala and R Suojaranta-Ylinen.
- Department of Surgery University Hospital of Kuopio, Finland. tapio.hakala@kolumbus.fi
- Ann Chir Gynaecol. 2000 Jan 1; 89 (2): 150-2.
Background And AimsAdministration of protamine might cause serious complications especially in patients treated preoperatively with NPH insulin.Material And MethodsA case report.Results And ConclusionAdministration of protamine sulphate caused fatal anaphylactic reaction to a diabetic patient undergoing femoropopliteal by-pass surgery. Care should be taken when administering protamine to a patient treated preoperatively with NPH insulin and the possibility of an anaphylactid reaction to protamine have to be kept in mind.
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