• J Cataract Refract Surg · Mar 1995

    Randomized Controlled Trial Comparative Study Clinical Trial

    Relative effectiveness of topical ketorolac and topical diclofenac on discomfort after radial keratotomy.

    • R L Epstein and E P Laurence.
    • Center for Corrective Eye Surgery, McHenry, Illinois 60050, USA.
    • J Cataract Refract Surg. 1995 Mar 1; 21 (2): 156-9.

    AbstractTwo prospective, randomized, double-masked studies were conducted evaluating the analgesic effect of topical eyedrops after radial keratotomy (RK). One study of 117 consecutive initial RK procedures compared topical ketorolac (Acular) with topical diclofenac (Voltaren), and another study of 23 consecutive initial RK procedures compared topical ketorolac with a control medication (HypoTears). Topical ketorolac was significantly more effective than the control but not significantly different from topical diclofenac. The onset of analgesic effect of these topical nonsteroidal anti-inflammatory drugs is longer than one hour. The analgesic effect of oral acetaminophen #3 significantly augments that of topical diclofenac drops for those experiencing any discomfort by six hours after surgery.

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