• Eur. J. Clin. Pharmacol. · Jan 1991

    Randomized Controlled Trial Clinical Trial

    Transdermal fentanyl for the treatment of pain after major urological operations. A randomized double-blind comparison with placebo using intravenous patient-controlled analgesia.

    • K A Lehmann, C Einnolf, H J Eberlein, and R Nagel.
    • Department of Anaesthesiology and Operative Intensive Care University of Cologne, Köln, FRG.
    • Eur. J. Clin. Pharmacol. 1991 Jan 1; 41 (1): 17-21.

    AbstractTransdermal fentanyl 75 micrograms/h (Fentanyl-TTS) was compared with placebo in a randomized double-blind study in the early postoperative period, using 50 patients recovering from major urological operations. Analgesic efficacy was individually titrated with intravenous fentanyl by means of a PCA pump (demand dose 34 micrograms, lockout time 5 min). The test systems were applied 8 h before anaesthesia and were left in situ for 24 h. During the PCA period (18.2 h) patients with Fentanyl-TTS required significantly less additional fentanyl (0.48 vs 0.93 micrograms.kg-1.h-1) and reported less pain than patients in the placebo-group. Patient acceptance was high in both groups. Side-effects were of only minor intensity and did not differ between the two groups. In particular, there was no case of clinically relevant respiratory depression.

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