• Acta Anaesthesiol Scand · Apr 1991

    Randomized Controlled Trial Comparative Study Clinical Trial

    Comparison of standard and high-dose adrenaline in the resuscitation of asystole and electromechanical dissociation.

    • K H Lindner, F W Ahnefeld, and A W Prengel.
    • Department of Anaesthesia, University of Ulm, Federal Republic of Germany.
    • Acta Anaesthesiol Scand. 1991 Apr 1; 35 (3): 253-6.

    AbstractSixty-eight adults with cardiac arrest (asystole and electromechanical dissociation) were randomly allocated for treatment with standard (1 mg) or high-dose epinephrine (5 mg). If the first dose of adrenaline (1 or 5 mg) failed, standardized advanced life-support was applied in all cases. High-dose adrenaline was associated with higher initial resuscitation success rates (16 of 28) than standard-dose adrenaline (6 of 40), whereas hospital discharge rates were not significantly different between the groups. Blood pressure was significantly higher in the high-dose adrenaline group in comparison to the standard dose at 1 and 5 min after resuscitation. Although high-dose adrenaline appears to improve cardiac resuscitation success, the duration of global cerebral ischaemia seems to determine the ultimate outcome.

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