• Med. Sci. Monit. · Aug 2005

    Cerebrospinal fluid tumor marker levels in predicting response to treatment and survival of carcinomatous meningitis in patients with advanced breast cancer.

    • Christos Kosmas, Nicolas B Tsavaris, George Tsakonas, Georgia Soukouli, Argyris Gassiamis, Nicolas Mylonakis, and Athanasios Karabelis.
    • Department of Medicine, 2nd Medical Oncology Division, Metaxa Cancer Hospital, Piraeus, Greece. ckosm@ath.forthnet.gr
    • Med. Sci. Monit. 2005 Aug 1; 11 (8): CR398-401.

    BackgroundThe aim of this study was to evaluate the predictive value of cerebrospinal fluid (CSF) tumor marker levels in patients with breast cancer and carcinomatous meningitis.Material/MethodsSerial CSF and serum tumor marker (CEA, CA-15.3, CA-125, and CA-19.9) measurements were performed in five patients with breast cancer developing carcinomatous meningitis in an attempt to correlate these with clinical outcome under treatment.ResultsCSF tumor marker levels correlated with response to treatment and outcome in each patient; despite achieving negative CSF cytology after therapy, in two patients it heralded disease progression.ConclusionsGiven our findings, CSF tumor marker evaluation may provide a reliable means and surrogate end-points of monitoring response of carcinomatous meningitis to treatment. Therefore, large studies to assess the value of CSF tumor marker changes in carcinomatous meningitis are warranted.

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