• Stephen B Williams, Mehrdad Alemozaffar, Yin Lei, Nathanael Hevelone, Stuart R Lipsitz, Blakely A Plaster, and Jim C Hu.
• Division of Urologic Surgery, Brigham and Women's Hospital, Boston, MA, USA.
• Eur. Urol. 2010 Dec 1; 58 (6): 875-81.

BackgroundTransperitoneal robot-assisted laparoscopic prostatectomy (RALP) urethrovesical anastomosis is a critical step. Although the prevalence of urine leaks ranges from 4.5% to 7.5% at high-volume RALP centers, urine leaks prolong catheterization and may lead to ileus, peritonitis, and require intervention. Barbed polyglyconate sutures maintain running suture line tension and may be advantageous in RALP anastomosis for reducing this complication.ObjectiveTo compare barbed polyglyconate and polyglactin 910 (Vicryl, Ethicon, Somerville, NJ, USA) running sutures for RALP anastomosis.Design, Setting, And ParticipantsThis was a prospective, randomized, controlled, single-surgeon study comparing RALP anastomosis using either barbed polyglyconate (n = 45) or polyglactin 910 (n = 36) sutures.Surgical ProcedureRALP anastomosis using either barbed polyglyconate or polyglactin 910 sutures was studied.MeasurementsOperative time, cost differential, perioperative complications, and cystogram contrast extravasation by anastomosis suture type were measured.Results And LimitationsAlthough baseline characteristics and overall operative times were similar, barbed polyglyconate sutures were associated with shorter mean anastomosis times of 9.7 min versus 9.8 min (p = 0.014). In addition, anastomosis with barbed polyglyconate rather than polyglactin 910 sutures was associated with more frequent cystogram extravasation 8 d postoperatively (20.0% vs 2.8%; p = 0.019), longer mean catheterization times (11.1 d vs 8.3 d; p = 0.048), and greater suture costs per case ($51.52 vs $8.44; p < 0.001). After 8 of 29 (27.6%) barbed polyglyconate anastomosis sites demonstrated postoperative day 8 cystogram extravasation, we modified our technique to avoid overtightening, reducing cystogram extravasation to 1 (6.3%) of 16 subsequent barbed polyglyconate anastomosis sites. Potential limitations include small sample size and the single-surgeon study design.ConclusionsCompared to traditional sutures, barbed polyglyconate is more costly and requires technical modification to avoid overtightening, delayed healing, and longer catheterization time following RALP.Copyright © 2010 European Association of Urology. Published by Elsevier B.V. All rights reserved.

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