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- E N Ali, B C Healy, L A Stazzone, B A Brown, H L Weiner, and S J Khoury.
- Partners MS Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. eman_c5@yahoo.com
- Mult. Scler. 2009 Feb 1; 15 (2): 272-4.
BackgroundDaclizumab is a humanized monoclonal antibody (mAb) that blocks the interleukin-2 receptor alpha subunit (IL-2R-alpha chain; CD25) expressed on activated T cells leading to the inhibition of T-cell expansion, thus strongly reduces brain inflammation in patients with multiple sclerosis (MS). Another mechanism is significant expansion of CD56 (bright) natural killer (NK) cells that in turn inhibit T-cell survival.ObjectiveAt the Partners MS center, we have been using Daclizumab in an open-label fashion in patients who fail first line therapy or non-standard immunosuppressive treatment. Our aim was to assess its safety and tolerability in our patient population.
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