• Anaesth Intensive Care · Apr 2007

    The cardiovascular effects of adrenaline, dobutamine and milrinone in rabbits using pressure-volume loops and guinea pig isolated atrial tissue.

    • C F Royse, A G Royse, R Rohrlach, C E Wright, and J A Angus.
    • Cardiovascular Therapeutics Unit, Department of Pharmacology and Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.
    • Anaesth Intensive Care. 2007 Apr 1; 35 (2): 180-8.

    AbstractThis study evaluated the effects of milrinone, adrenaline and dobutamine with pressure-volume loops and isolated atrial tissue. Agonist dose-response curves to incremental drug infusions were acquired in 11 anesthetised rabbits using pressure-volume loops and preload recruitable stroke work indicated contractility. Agonist concentration-response curves were completed in eight guinea pig isolated atria, for effects on atrial rate and force. Adrenaline and dobutamine increased contractility (P = 0.006 and 0.044), whereas milrinone did not (P = 0.895). Only adrenaline increased myocardial stiffness (P < 0.001). Milrinone decreased vascular resistance (P < 0.001) and elicited the greatest fall in mean arterial pressure (P < 0.001) and increased ejection fraction (P < 0.001). Adrenaline decreased heart rate (P < 0.001), whereas dobutamine and milrinone increased it (P = 0.006 and 0.011). Milrinone increased the force of left atrial contraction, but its inotropic effect was weak and significantly less than with dobutamine and adrenaline (P < 0.001). Adrenaline acted as an inoconstrictor, dobutamine an inodilator and milrinone predominantly a vasodilator

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