• P Weeke, A Jensen, F Folke, G H Gislason, J B Olesen, E L Fosbøl, M Wissenberg, F K Lippert, E F Christensen, S L Nielsen, E Holm, J K Kanters, H E Poulsen, L Køber, and C Torp-Pedersen.
• Department of Cardiology, Copenhagen University Hospital, Gentofte, Denmark.
• Clin. Pharmacol. Ther. 2014 Oct 1; 96 (4): 490-7.

AbstractAntipsychotic drugs have been associated with sudden cardiac death, but differences in the risk of out-of-hospital cardiac arrest (OHCA) associated with different antipsychotic drug classes are not clear. We identified all OHCAs in Denmark (2001-2010). The risk of OHCA associated with antipsychotic drug use was evaluated by conditional logistic regression analysis in case-time-control models. In total, 2,205 (7.6%) of 28,947 OHCA patients received treatment with an antipsychotic drug at the time of the event. Overall, treatment with any antipsychotic drug was associated with OHCA (odds ratio (OR) = 1.53, 95% confidence interval (CI): 1.23-1.89), as was use with typical antipsychotics (OR = 1.66, CI: 1.27-2.17). By contrast, overall, atypical antipsychotic drug use was not (OR = 1.29, CI: 0.90-1.85). Two individual typical antipsychotic drugs, haloperidol (OR = 2.43, CI: 1.20-4.93) and levomepromazine (OR = 2.05, CI: 1.18-3.56), were associated with OHCA, as was one atypical antipsychotic drug, quetiapine (OR = 3.64, CI: 1.59-8.30).

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