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Case Reports
Lacosamide-induced second-degree atrioventricular block in a patient with partial epilepsy.
- Ahmad Nizam, Krishna Mylavarapu, Dwithiya Thomas, Klara Briskin, Brenda Wu, Deepak Saluja, and Stephen Wong.
- Department of Neurology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901-1962, USA.
- Epilepsia. 2011 Oct 1; 52 (10): e153-5.
AbstractDose-dependent PR interval prolongation has been reported in preclinical studies of lacosamide (LCM), a recently U.S. Food and Drug Administration (FDA)-approved antiepileptic drug (AED). Here we report a case of second-degree atrioventricular block (AV) block caused by the addition of LCM to other AEDs known to prolong the PR interval, resulting in hypotension and bradycardia, with consequent seizure exacerbation. The patient recovered completely after withdrawal of LCM. This case demonstrates the need for caution and interval cardiac testing when adding LCM to other AEDs known to prolong the PR interval.Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.
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