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- Franciele do Nascimento Santos, Mirian Watanabe, Carolina Ferreira Vasco, Cassiane Dezoti da Fonseca, and Maria de Fatima Fernandes Vattimo.
- School of Nursing, Universidade de São Paulo, São Paulo, SP, Brazil.
- Rev Esc Enferm Usp. 2014 Oct 1; 48 (5): 820-6.
ObjectiveEvaluating the effect of preconditioning with simvastatin in acute kidney injury induced by sepsis.MethodMale adult Wistar rats were divided into the following groups: SHAM (control); SHAM+Statin (0.5 mg/kg simvastatin, orally); Sepsis (cecal puncture ligation - CPL); Sepsis+Statin. Physiological parameters, peritoneal fluid culture, renal function, oxidative metabolites, severity of acute kidney injury and animal survival were evaluated.ResultsThe treatment with simvastatin in induced sepsis showed elevation of creatinine clearance with attenuation of generation of oxidative metabolites, lower severity of acute kidney injury and reduced mortality.ConclusionThis investigation confirmed the renoprotection with antioxidant principle of the simvastatin in acute kidney injury induced by sepsis in an experimental model.
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