• Obstetrics and gynecology · Feb 2007

    Case Reports

    Recombinant factor VIIa to successfully manage disseminated intravascular coagulation from amniotic fluid embolism.

    • Soumathy C Prosper, Christine S Goudge, and Virginia R Lupo.
    • Department of Maternal Fetal Medicine, Hennepin County Medical Center, Minneapolis, Minnesota 55415, USA.
    • Obstet Gynecol. 2007 Feb 1; 109 (2 Pt2): 524-5.

    BackgroundAmniotic fluid embolism (AFE) is a rare syndrome that can complicate pregnancy and labor. It often has debilitating and lethal consequences. One serious sequela of AFE is disseminated intravascular coagulation (DIC).CaseThis report describes an atypical presentation of AFE manifested by sudden fetal bradycardia and complicated by maternal DIC. The DIC was eventually successfully treated with the use of recombinant activated factor VIIa.ConclusionThe use of recombinant activated factor VIIa in cases of massive hemorrhage, such as in our patient, is controversial but has been shown, in some cases, to reverse DIC and be successful. The use of recombinant activated factor VIIa should be considered in patients with massive obstetric hemorrhage in whom standard measures of stabilization are unsuccessful.

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