• Anaesthesia · May 1992

    Randomized Controlled Trial Clinical Trial

    Epidural pethidine and bupivacaine in labour.

    • N D Edwards, M Hartley, P Clyburn, and M Harmer.
    • University Hospital of Wales, Heath Park, Cardiff.
    • Anaesthesia. 1992 May 1; 47 (5): 435-7.

    AbstractA double-blind randomised study was performed to assess the value of the addition of pethidine 50 mg to the initial dose of bupivacaine given for epidural analgesia in labour. Forty-nine patients received either 1 ml of saline (n = 24), or 50 mg of pethidine (n = 25), added to 9 ml of 0.25% bupivacaine as an initial injection for intrapartum epidural analgesia. There was a significant increase in the mean duration of analgesia in the pethidine group. However, pethidine did not increase the speed of onset of analgesia, or improve the quality of analgesia.

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