• Indian J Pediatr · Nov 2006

    Randomized Controlled Trial Comparative Study

    Comparative study of intranasal midazolam and intravenous diazepam sedation for procedures and seizures.

    • Pankaj Mittal, Ram Manohar, and A K Rawat.
    • Department of Pediatrics, S.S. Medical College and G.M. Hospital, Rewa, India.
    • Indian J Pediatr. 2006 Nov 1; 73 (11): 975-8.

    ObjectiveTo evaluate the safety and efficacy of intranasal midazolam for seizures and various procedures.MethodsProspective randomized study. Total 125 children of all ages of either sex, for seizure episode (n-76) and various invasive and non-invasive procedures (n-49) received either intranasal midazolam (0.2 mg/Kg) or intravenous diazepam (0.3 mg/Kg). RESULTS. Mean time from arrival at hospital to starting treatment was significantly shorter in midazolam group compared to diazepam group [2.34+/-0.90; minute vs 4.61+/-1.08 minute p< 0.001]. Mean time to control seizures after arrival in hospital was significantly shorter in midazolam group compared to diazepam group [5.25+/-0.86 minute vs 6.51+/-1.06 minute p.ConclusionMidazolam by the intranasal route provides safe and equally effective non-invasive method of sedation for procedures and seizures.

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