• J. Immunol. · May 2007

    Review

    Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation.

    • Silvio Danese, Elisabetta Dejana, and Claudio Fiocchi.
    • Instituto di Ricerca e Cura a Carattere Scientifico Istituto Clinico Humanitas, Milan, Italy. sdanes@hotmail.com
    • J. Immunol. 2007 May 15; 178 (10): 6017-22.

    AbstractAn effective immune response depends not only on the proper activation, regulation, and function of immune cells, but also on their distribution and retention in diverse tissue microenvironments where they encounter a number of stimuli and other cell types. These activities are mediated by endothelial cells, which form specialized microcirculatory networks used by immune cells under both physiological and pathological circumstances. Endothelial cells represent a highly heterogeneous population of cells with the ability to interact with and modulate the function of immune cells. This review is focused on the role of microvascular endothelial cells in innate and adaptive immunity, inflammation, coagulation, angiogenesis, and the therapeutic implications of targeting endothelial cells in selected autoimmune and chronic inflammatory disorders.

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