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Ther Clin Risk Manag · Jan 2015
ReviewTapentadol extended release in the management of peripheral diabetic neuropathic pain.
- Nalini Vadivelu, Alice Kai, Benjamin Maslin, Gopal Kodumudi, Aron Legler, and Jack M Berger.
- Department of Anesthesiology, Yale University School of Medicine, New Haven, CT, USA.
- Ther Clin Risk Manag. 2015 Jan 1; 11: 95-105.
AbstractTapentadol, a μ-opioid agonist and norepinephrine reuptake inhibitor, has been found to be an effective medication for a wide variety of chronic pain conditions, including back pain, cancer-related pain, and arthritic pain. It has also been found to have fewer gastrointestinal side effects than more traditional opioid-based therapies. More recently, tapentadol extended release has been demonstrated to be effective in the management of painful diabetic neuropathy, an often debilitating condition affecting approximately one-third of all patients with diabetes. This review highlights the most up-to-date basic and clinical studies by focusing on the mechanisms of action of tapentadol and its clinical efficacy, especially with regard to painful diabetic neuropathy.
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