• Nefrologia · Jan 2010

    Case Reports

    [Goodpasture's syndrome with neurologic involvement and negative ANCA].

    • G Pérez-Suárez, D Marrero, R Rodríguez, P Delgado, M Cobo, J M González-Posada, and D Hernández.
    • Servicio de Nefrología, Hospital Universitario de Canarias, La Laguna, Tenerife. gpersuarez@gmail.com
    • Nefrologia. 2010 Jan 1; 30 (5): 584-7.

    AbstractGoodpasture's syndrome is a rare autoimmune disorder characterized by rapidly progressive glomerulonephritis (RPGN) and alveolar hemorrhage in the presence of antiglomerular basement membrane (anti-GBM) antibodies. Central nervous system involvement is highly unusual in the absence of anti-neutrophil cytoplasmic antibodies. We report the case of a 20-year-old man with RPGN accompanied by bloody sputum, tonic-clonic seizure and high titers of anti-GBM antibody. After treatment with immunosuppressants and plasmapheresis, the patient showed reduced anti-GBM antibody titers and improved neurologic and respiratory symptoms, but renal failure persisted, requiring hemodialysis. Twenty months later, with the disease in remission, he underwent deceased-donor renal transplantation.

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