• Oncology Ny · Jul 1988

    Managing carcinomas of unknown primary site.

    • J D Hainsworth and F A Greco.
    • Division of Oncology, Vanderbilt University, School of Medicine.
    • Oncology Ny. 1988 Jul 1; 2 (7): 43-9, 52-4.

    AbstractPatients with carcinoma of unknown primary site are heterogeneous with respect to tumor biology, clinical characteristics, and response to therapy. These patients should no longer be considered uniformly "untreatable"; careful evaluation can identify treatable subsets. The initial light microscopic findings should be used to categorize patients into one of three groups: Well-differentiated adenocarcinoma, poorly differentiated carcinoma (or adenocarcinoma), and squamous carcinoma. Subsequent evaluation and treatment differ for these three groups. Poorly differentiated carcinomas are often responsive to cisplatin-based chemotherapy; effective systemic treatments are also available for some subsets of patients with adenocarcinoma. Surgery and/or radiotherapy is often beneficial for patients with squamous carcinoma, especially those who have isolated cervical lymphadenopathy.

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