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J. Matern. Fetal. Neonatal. Med. · Feb 2017
Clinical TrialAnalysis of urine biomarkers for early determination of acute kidney injury in non-septic and non-asphyxiated critically ill preterm neonates.
- A T Elmas, A Karadag, Y Tabel, R Ozdemir, and G Otlu.
- a Department of Pediatric Nephrology.
- J. Matern. Fetal. Neonatal. Med. 2017 Feb 1; 30 (3): 302-308.
ObjectiveWe designed the present study to test the hypothesis that urinary biomarkers might predict acute kidney injury (AKI) development in non-septic and non-asphyxiated critically ill preterm infants. We evaluated urine (u) sistatin-C (uCys-C), kidney injury molecule-1 (uKIM-1) and neutrophil gelatinase associate lipocaline (uNGAL) as markers of AKI.MethodsSixty-four preterm infants with gestational age between 28 and 32 weeks were included in this study. Biomarkers were measured on day of life (DOL) 1, 3, and 7.ResultsuNGAL levels in the AKI group were significantly higher than in no-AKI group on DOL 1, 3 and 7 (p = 0.016, p = 0.007 and p = 0.0014, respectively).ConclusionsuNGAL is sensitive, early, and noninvasive AKI biomarkers, increasing significantly in non-septic and non-asphyxiated critically ill preterm neonates.
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