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Clinical endocrinology · Jun 2009
How should a nonfunctioning pituitary macroadenoma be monitored after debulking surgery?
- Yona Greenman and Naftali Stern.
- Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. greenman@tasmc.heatlh.gov.il
- Clin. Endocrinol. (Oxf). 2009 Jun 1; 70 (6): 829-32.
AbstractTranssphenoidal surgery is the treatment of choice for nonfunctioning pituitary macroadenomas but is seldom curative. Tumour progression rates are high in patients with postoperative remnants. Therefore, long-term monitoring is necessary to detect tumour growth, which may be asymptomatic or manifest with visual field defects and/or pituitary dysfunction. In view of the generally slow-growing nature of these tumours, yearly magnetic resonance imaging, neuro-ophthalmologic and pituitary function evaluation are appropriate during the first 3-5 years after surgery. If there is no evidence for tumour progression during this period, testing intervals may be extended thereafter.
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