• I K Neonakis, G Samonis, H Messaritakis, S Baritaki, A Georgiladakis, S Maraki, and D A Spandidos.
• Department of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, University Hospital of Heraklion, Heraklion, Greece. ineonakis@gmail.com
• Chemotherapy. 2010 Jan 1; 56 (6): 448-52.

BackgroundDue to its increased non-susceptibility rates, Klebsiella pneumoniae has emerged as one of the most problematic pathogens.MethodsThe level of resistance to 25 antimicrobials of K. pneumoniae isolates from a teaching hospital in Greece and the evolution trends during 2 decades were examined.ResultsA statistically significant increase in non-susceptibility rates was found for almost all antimicrobials examined. During 2008, the isolates presented non-susceptibility rates to aminoglycosides >50% and to quinolones >60%. Nowadays, 1 out of 10 isolates is non-susceptible to colistin. Moreover, the isolates non-susceptible to imipenem were almost doubled between 2007 (29%) and 2008 (50%). Among the imipenem-resistant isolates, 1 out of 4 was also resistant to colistin.ConclusionThe effectiveness of carbapenems has been compromised and the increase in resistance to colistin is rapid and steep.Copyright © 2010 S. Karger AG, Basel.

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