• Delphine De Smedt, Els Clays, Frank Doyle, Kornelia Kotseva, Christof Prugger, Andrzej Pająk, Catriona Jennings, David Wood, Dirk De Bacquer, and EUROASPIRE Study Group.
• Department of Public Health, Ghent University, Gent, Belgium. Electronic address: Delphine.desmedt@ugent.be.
• Int. J. Cardiol. 2013 Sep 1; 167 (5): 2294-9.

ObjectiveTo investigate the validity and reliability of the EuroQol-5D (EQ-5D), the 12-item Short-Form Health Survey (SF-12v2), and the Hospital Anxiety and Depression Scale (HADS) in a stable coronary population.Study DesignCross-sectional study EUROASPIRE III.SettingQuality of life data (QoL) were available on 8745 patients hospitalized for coronary artery bypass graft (CABG), percutaneous coronary intervention (PCI), acute myocardial infarction (AMI), or myocardial ischemia. They were interviewed and examined at least 6 months after their hospital admission. Reliability and validity of the 3 instruments were tested. Internal consistency, and discriminative, convergent, criterion and construct validity were assessed.ResultsCronbach's alpha indicated good internal consistency for all measures (0.73 to 0.87). Discriminative validity analyses confirmed significant QoL differences between known groups: age, gender, educational level. In addition, all hypothesized correlations between QoL constructs (convergent validity) and items (criterion validity) were confirmed with significant correlations. Confirmatory factor analyses indicated good construct validity for HADS and SF-12v2. On country-specific level, results were roughly similar.ConclusionThe EQ-5D as well as the SF-12v2 and the HADS are reliable and valid instruments for use in a stable coronary population, both on aggregate European level and on country-specific level. However, our results must be generalized with caution, because EUROASPIRE III patients might not be representative for all patients with stable coronary heart disease.Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

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